Redox signaling and oxidative stress: Cross talk with TNF-related apoptosis inducing ligand activity
نویسندگان
چکیده
منابع مشابه
A "cross-talk" between Oxidative Stress and Redox Cell Signaling
Cells are sensitive to a variety of signals in their environment, which they respond to and integrate. Signal transduction at the cellular level refers to the movement of signals from outside the cell to inside. A "cross-talk" between heterologous cell signaling systems gives a complex communication of molecules in various tissues a new dimension and specifies the type of the obtained biologica...
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Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L (Apo-2 ligand), is a cytokine of the TNF superfamily acknowledged for its ability to trigger selective apoptosis in tumor cells while being relatively safe towards normal cells. Its binding to its cognate agonist receptors, namely death receptor 4 (DR4) and/or DR5, can induce the formation of a membrane-bound ...
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Molecular farming has been considered as a secure and economical approach for production of biopharmaceuticals. Human TNF Related Apoptosis Inducing Ligand (TRAIL) as a promising biopharmaceutical candidate has been produced in different expression hosts. However, little attention has been paid to molecular farming of the TRAIL in spite of numerous advantages of plant expression systems. Theref...
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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of TNF family, is an interesting ligand which selectively induces apoptosis in tumor cells and, therefore, it has been developed for cancer therapy. This ligand has been produced by various hosts such as E.coli. However, protein expression in E.coli cytoplasm leads to problems such as incorrect folding, reduction in biolo...
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ژورنال
عنوان ژورنال: The International Journal of Biochemistry & Cell Biology
سال: 2016
ISSN: 1357-2725
DOI: 10.1016/j.biocel.2016.09.019